The paper highlights The Multi-Disciplinary Optimization of Radial and Mixed-Inflow Turbines for Turbochargers. The radial and mixed-inflow turbines have been widely used for the turbocharger application. The design of a turbocharger turbine with good performance still presents a lot of challenges. Apart from the traditional requirements such as high efficiency and low stress, the turbine blade is also required to achieve certain performance targets at multiple operating points, high unsteady efficiency under pulsating flow condition, reduced moment of inertia (MOI) and high vibration characteristic.